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Neurons
Thu, January 1, 2015
Restoring Lost Memories in Early Alzheimer's Patients Study
A study focusing on the Aplysias, a snail with similar cellular and molecular functions as ours, holds promise for restoring memory. The study, published in the journal eLife, was done by a research team at UCLA, and suggests that memory is stored, not in the synapses, but somewhere else.

The team trained the snails using mild electric shocks to their tails. Through studying the serotonin and proteins produced in the creation of memory the team was able to identify that long-term memories are able to be restored as long as the neurons are alive. They also studied the impact of inhibiting protein synthesis in memory storage. Proteins play a role in the creation of new synpases.

Senior author David Glanzman states, "That suggests that the memory is not in the synapses but somewhere else," says Glanzman. "We think it's in the nucleus of the neurons. We haven't proved that, though. Long-term memory is not stored at the synapse. That's a radical idea, but that's where the evidence leads. The nervous system appears to be able to regenerate lost synaptic connections. If you can restore the synaptic connections, the memory will come back. It won't be easy, but I believe it's possible."

The study may provide hope for those with early-stage Alzheimer's. For more information about this study please visit http://www.medicalnewstoday.com/articles/287360.php.

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